Description
Product Characteristics:
Aliases: I kappa B related protein antibody, I-kappa-B-related protein antibody, IkappaBR antibody, IKBR antibody, Inhibitor of kappa B related protein antibody, Inhibitor of kappa B-related protein antibody, MMS22L-interacting protein antibody, MMS22L-interacting protein, NFBIL2/TONSL antibody, NF kappa B inhibitor like protein 2 antibody, NF-kappa-B inhibitor-like protein 2 antibody, NFBIL2 antibody, NFBIL2/TONSL antibody, Nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor like protein 2 antibody, Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 2 antibody, Protein IkappaBR antibody, Tonsl antibody, TONSL_HUMAN antibody, Tonsoku-like protein antibody, tonsoku-like, DNA repair protein antibody
Target Information: The protein encoded by this gene is thought to be a negative regulator of NF-kappa-B mediated transcription. The encoded protein may bind NF-kappa-B complexes and trap them in the cytoplasm, preventing them from entering the nucleus and interacting with the DNA. Phosphorylation of this protein targets it for degradation by the ubiquitination pathway, which frees the NF-kappa-B complexes to enter the nucleus. [provided by RefSeq, Jul 2008]